Lehninger Principles of Biochemistry 7ED ISBN 9781464126116

Lehninger Principles of Biochemistry 

David L. Nelson /Michael M. Cox 

ISBN 9781464126116

Lehninger Principles of Biochemistry is the #1 bestseller for the introductory biochemistry course because it brings clarity and coherence to an often unwieldy discipline, offering a thoroughly updated survey of biochemistry’s enduring principles, definitive discoveries, and groundbreaking new advances with each edition.

This new Seventh Edition maintains the qualities that have distinguished the text since Albert Lehninger’s original edition—clear writing, careful explanations of difficult concepts, helpful problem-solving support, and insightful communication of contemporary biochemistry’s core ideas, new techniques, and pivotal discoveries. Again, David Nelson and Michael Cox introduce students to an extraordinary amount of exciting new findings without an overwhelming amount of extra discussion or detail. And with this edition, W.H. Freeman and Sapling Learning have teamed up to provide the book’s richest, most completely integrated text/media learning experience yet, through an extraordinary new online resource: SaplingPlus.

1. The Foundations of Biochemistry

1.1 Cellular Foundations/1.2 Chemical Foundations/Box 1–1 Molecular Weight, Molecular Mass, and Their Correct Units /Box 1–2 Louis Pasteur and Optical Activity: In Vino, Veritas /1.3 Physical Foundations /Box 1–3 Entropy: Things Fall Apart /1.4 Genetic Foundations

2. Water

2.1 Weak Interactions in Aqueous Systems/2.2 Ionization of Water, Weak Acids, and Weak Bases/2.3 Buffering agains pH Changes in Biological Systems/Box 2-1 Medicine: On Being One's Own Rabbit (Don't Try This at Home!)/2.4 Water as a Reactant/2.5 The Fitness of Aqueous Environment for Living Organisms
 
3. Amino Acids, Peptides, and Proteins
3.1 Amino Acids/Box 3-1 Methods: Absorption of Light by Molecules: The Lambert-Beer Law/3.2 Peptides and Proteins /3.3 Working with Proteins /3.4 The Structure of Proteins: Primary Structure  /Box 3–2 Consensus Sequences and Sequence Logos

4. The Three-Dimensional Structure of Proteins  
4.1 Overview of Protein Structure /4.2 Protein Secondary Structure /Box 4–1 Methods: Knowing the Right Hand from the Left  /4.3 Protein Tertiary and Quaternary Structures /Box 4–2 Permanent Waving Is Biochemical Engineering /Box 4–3 Why Sailors, Explorers, and College Students Should Eat Their Fresh Fruits and Vegetables /Box 4–4 The Protein Data Bank /Box 4–5 Methods: Methods for Determining the Three-Dimensional Structure of a Protein /4.4 Protein Denaturation and Folding /Box 4–6 Medicine: Death by Misfolding: The Prion Diseases

5. Protein Function

5.1 Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins /Box 5–1 Medicine: Carbon Monoxide: A Stealthy Killer /5.2 Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins /5.3 Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors 

6. Enzymes 

6.1 An Introduction to Enzymes /6.2 How Enzymes Work / 6.3 Enzyme Kinetics as an Approach to Understanding Mechanism/Box 6–1 Transformations of the Michaelis-Menten Equation: The Double-Reciprocal Plot/Box 6–2 Kinetic Tests for Determining Inhibition Mechanisms /Box 6–3 Curing African Sleeping Sickness with a Biochemical Trojan Horse /6.4 Examples of Enzymatic Reactions /6.5 Regulatory Enzymes

7. Carbohydrates and Glycobiology 

7.1 Monosaccharides and Disaccharides /Box 7–1 Medicine: Blood Glucose Measurements in the Diagnosis and Treatment of Diabetes /Box 7–2 Sugar Is Sweet, and So Are a Few Other Things /7.2 Polysaccharides 
7.3 Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids /7.4 Carbohydrates as Informational Molecules: The Sugar Code  /7.5 Working with Carbohydrates 

8. Nucleotides and Nucleic Acids

8.1 Some Basics /8.2 Nucleic Acid Structure /8.3 Nucleic Acid Chemistry /8.4 Other Functions of Nucleotides 

9.  DNA-Based Information Technologies 

9.1 Studying Genes and Their Products /Box 9–1 A Powerful Tool in Forensic Medicine /9.2 Using DNA-Based Methods to Understand Protein Function /9.3 Genomics and the Human Story /Box 9–2 Medicine: Personalized Genomic Medicine /Box 9–3 Getting to Know the Neanderthals 

10. Lipids 

10.1 Storage Lipids /10.2 Structural Lipids in Membranes /Box 10–1 Medicine: Abnormal Accumulations of Membrane Lipids: Some Inherited Human Diseases /10.3 Lipids as Signals, Cofactors, and Pigments  /10.4 Working with Lipids

11. Biological Membranes and Transport

11.1 The Composition and Architecture of Membranes /11.2 Membrane Dynamics /11.3 Solute Transport across Membranes /Box 11–1 Medicine: Defective Glucose and Water Transport in Two Forms of Diabetes/Box 11–2 Medicine: A Defective Ion Channel in Cystic Fibrosis

12. Biosignaling 

12.1 General Features of Signal Transduction  /Box 12–1 Methods Scatchard Analysis Quantifies the Receptor-Ligand Interaction /12.2 Protein–Coupled Receptors and Second Messengers /Box 12–2 Medicine: G Proteins: Binary Switches in Health and Disease /Box 12–3 Methods: FRET: Biochemistry Visualized in a Living Cell /12.3 Receptor Tyrosine Kinases /12.4 Receptor Guanylyl Cyclases, cGMP, and Protein Kinase G /12.5 Multivalent Adaptor Proteins and Membrane Rafts /12.6 Gated Ion Channels /12.7 Integrins: Bidirectional Cell Adhesion Receptors /12.8 Regulation of Transcription by Nuclear Hormone Receptors /12.9 Signaling in Microorganisms and Plants /12.10 Sensory Transduction in Vision, Olfaction, and Gustation /Box 12–4 Medicine: Color Blindness: John Dalton’s Experiment from the Grave  /12.11 Regulation of the Cell Cycle by Protein Kinases /12.12 Oncogenes, Tumor Suppressor Genes, and Programmed Cell Death /Box 12–5 Medicine: Development of Protein Kinase Inhibitors for Cancer Treatment

13. Bioenergetics and Biochemical Reaction Types 

13.1 Bioenergetics and Thermodynamics /13.2 Chemical Logic and Common Biochemical Reactions /13.3 Phosphoryl Group Transfers and ATP /Box 13–1 Firefly Flashes: Glowing Reports of ATP  /13.4 Biological Oxidation-Reduction Reactions

14. Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway 

14.1 Glycolysis /Box 14–1 Medicine: High Rate of Glycolysis in Tumors Suggests Targets for Chemotherapy and Facilitates Diagnosis  /14.2 Feeder Pathways for Glycolysis /14.3 Fates of Pyruvate under Anaerobic Conditions: Fermentation  /Box 14–2 Athletes, Alligators, and Coelacanths: Glycolysis at Limiting Concentrations of Oxygen /Box 14–3 Ethanol Fermentations: Brewing Beer and Producing Biofuels/14.4 Gluconeogenesis /14.5 Pentose Phosphate Pathway of Glucose Oxidation /Box 14–4 Medicine: Why Pythagoras Wouldn’t Eat Falafel: Glucose 6-Phosphate Dehydrogenase Deficiency

15. Principles of Metabolic Regulation 

15.1 Regulation of Metabolic Pathways /15.2 Analysis of Metabolic Control  /Box 15–1 Methods: Metabolic Control Analysis: Quantitative Aspects /15.3 Coordinated Regulation of Glycolysis and Gluconeogenesis /Box 15–2 Isozymes: Different Proteins That Catalyze the Same Reaction /Box 15–3 Medicine: Genetic Mutations That Lead to Rare Forms of Diabetes /15.4 The Metabolism of Glycogen in Animals /Box 15–4 Carl and Gerty Cori: Pioneers in Glycogen Metabolism and Disease /15.5 Coordinated Regulation of Glycogen Synthesis and Breakdown

16. The Citric Acid Cycle 

16.1 Production of Acetyl-CoA (Activated Acetate) /16.2 Reactions of the Citric Acid Cycle /Box 16–1 Moonlighting Enzymes: Proteins with More Than One Job  /Box 16–2  Synthases and Synthetases; Ligases and Lyases; Kinases, Phosphatases, and Phosphorylases: Yes, the Names Are Confusing! /Box 16–3 Citrate: A Symmetric Molecule That Reacts Asymmetrically /16.3 Regulation of the Citric Acid Cycle /16.4 The Glyoxylate Cycle

17. Fatty Acid Catabolism 

17.1 Digestion, Mobilization, and Transport of Fats /17.2 Oxidation of Fatty Acids /Box 17–1 Fat Bears Carry Out βOxidation in Their Sleep /Box 17–2 Coenzyme B12: A Radical Solution to a Perplexing Problem  /17.3 Ketone Bodies 

18. Amino Acid Oxidation and the Production of Urea 

18.1 Metabolic Fates of Amino Groups /18.2 Nitrogen Excretion and the Urea Cycle /Box 18–1 Medicine: Assays for Tissue Damage /18.3 Pathways of Amino Acid Degradation /Box 18–2 Medicine:Scientific Sleuths Solve a Murder Mystery 

19.  Oxidative Phosphorylation and Photophosphorylation Oxidative Phosphorylation 

19.1 Electron-Transfer Reactions in Mitochondria /Box 19–1 Hot, Stinking Plants and Alternative Respiratory Pathways  /19.2 ATP Synthesis /Box 19–2 Methods: Atomic Force Microscopy to Visualize Membrane Proteins /19.3 Regulation of Oxidative Phosphorylation /19.4 Mitochondria in Thermogenesis, Steroid Synthesis, and Apoptosis /19.5 Mitochondrial Genes: Their Origin and the Effects of Mutations  /Photosynthesis: Harvesting Light Energy/19.6 General Features of Photophosphorylation /19.7 Light Absorption /19.8 The Central Photochemical Event: Light-Driven Electron Flow  /19.9 ATP Synthesis by Photophosphorylation /19.10 The Evolution of Oxygenic Photosynthesis

20. Carbohydrate Biosynthesis in Plants and Bacteria

20.1 Photosynthetic Carbohydrate Synthesis /20.2 Photorespiration and the C4 and CAM Pathways /Box 20–1 Will Genetic Engineering of Photosynthetic Organisms Increase Their Efficiency?/20.3 Biosynthesis of Starch and Sucrose /20.4 Synthesis of Cell Wall Polysaccharides: Plant Cellulose and Bacterial Peptidoglycan /20.5 Integration of Carbohydrate Metabolism in the Plant Cell 

21. Lipid Biosynthesis 

21.1 Biosynthesis of Fatty Acids and Eicosanoids /Box 21–1 Medicine: Mixed-Function Oxidases, Cytochrome P-450s and Drug Overdoses /21.2 Biosynthesis of Triacylglycerols /21.3 Biosynthesis of Membrane Phospholipids /21.4 Cholesterol, Steroids, and Isoprenoids: Biosynthesis, Regulation, and Transport  /Box 21–2 Medicine: ApoE Alleles Predict Incidence of Alzheimer’s Disease /Box 21–3 Medicine: The Lipid Hypothesis and the Development of Statins

22. Biosynthesis of Amino Acids, Nucleotides, and Related Molecules 

22.1 Overview of Nitrogen Metabolism /Box 22–1 Unusual Lifestyles of the Obscure but Abundant /22.2 Biosynthesis of Amino Acids  /22.3 Molecules Derived from Amino Acids /Box 22–2 On Kings and Vampires /22.4 Biosynthesis and Degradation of Nucleotides

23. Hormonal Regulation and Integration of Mammalian Metabolism  

23.1 Hormones: Diverse Structures for Diverse Functions /Box 23–1 Medicine: How Is a Hormone Discovered? The Arduous Path to Purified Insulin /23.2 Tissue-Specific Metabolism: The Division of Labor  /Box 23–2 Creatine and Creatine Kinase: Invaluable Diagnostic Aids and the Muscle Builder’s Friends /23.3 Hormonal Regulation of Fuel Metabolism /23.4 Obesity and the Regulation of Body Mass /23.5 Obesity, the Metabolic Syndrome, and Type 2 Diabetes

24. Genes and Chromosomes 

24.1 Chromosomal Elements /24.2 DNA Supercoiling /Box 24–1 Medicine: Curing Disease by Inhibiting Topoisomerases /24.3 The Structure of Chromosomes /Box 24–2 Medicine: Epigenetics, Nucleosome Structure, and Histone Variants

25. DNA Metabolism 

25.1 DNA Replication /25.2 DNA Repair /Box 25–1 Medicine: DNA Repair and Cancer /25.3 DNA Recombination /Box 25–2 Medicine:Why Proper Chromosomal Segregation Matters

26. RNA Metabolism 

26.1 DNA-Dependent Synthesis of RNA  /Box 26–1 Methods: RNA Polymerase Leaves Its Footprint on a Promoter  /26.2 RNA Processing  /26.3 RNA-Dependent Synthesis of RNA and DNA  /Box 26–2 Medicine: Fighting AIDS with Inhibitors of HIV Reverse Transcriptase /Box 26–3 Methods: The SELEX Method for Generating RNA Polymers with New Functions /Box 26–4 An Expanding RNA Universe Filled with TUF RNAs

27. Protein Metabolism 

27.1 The Genetic Code /Box 27–1 Exceptions That Prove the Rule: Natural Variations in the Genetic Code /27.2 Protein Synthesis /Box 27–2 From an RNA World to a Protein World /Box 27–3 Natural and Unnatural Expansion of the Genetic Code /Box 27–4 Induced Variation in the Genetic Code: Nonsense Suppression  
27.3 Protein Targeting and Degradation

28. Regulation of Gene Expression

28.1 Principles of Gene Regulation  /28.2 Regulation of Gene Expression in Bacteria /28.3 Regulation of Gene Expression in Eukaryotes /Box 28–1 Of Fins, Wings, Beaks, and Things

Appendix A Common Abbreviations in the Biochemical Research Literature 

Appendix B Abbreviated Solutions to Problems 
Glossary 
Credits 
Index